Despite

(prep.)

without being affected by (the factors mentioned)

尽管；不管；不顾

e.g. The had a wonderful holiday, despite the bad weather.

尽管天气不好，他们在假日还是过得极为愉快。

e.g. Despite wanting to see him again, she refused to reply to his letters.

她尽管很想再见到他，但却不愿给他回信。

e.g. Despite what others say, I think he's a very nice chap.

不管别人怎么说，我仍认为他这个人很好。

e.g. John is handsome despite the scar on his face.

尽管有一道伤疤在约翰的脸上，但是他仍然很帅。

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